It is the standard builds of Python include an object-oriented interface to the Tcl/Tk widget set, called tkinter. This is probably the easiest to install and use (since it comes included with most binary distributions of Python).
**2. wxPython**
It is an open source, portable GUI class library written in C++ that provides a native look and feel on a number of platforms, with Windows, Mac OS X, GTK, X11, all listed as current stable targets. Language bindings are available for a number of languages including Python, Perl, Ruby, etc.
**3. Qt**
It has bindings available for the Qt toolkit (using either PyQt or PySide) and for KDE (PyKDE4). PyQt is currently more mature than PySide, but you must buy a PyQt license from Riverbank Computing if you want to write proprietary applications. PySide is free for all applications.
**4. Kivy**
It is a cross-platform GUI library supporting both desktop operating systems (Windows, macOS, Linux) and mobile devices (Android, iOS). It is written in Python and Cython, and can use a range of windowing backends.
Kivy is free and open source software distributed under the MIT license.
**5. Gtk+**
The GObject introspection bindings for Python allow you to write GTK+ 3 applications.
The older PyGtk bindings for the Gtk+ 2 toolkit have been implemented by James Henstridge.
