diff --git a/web3.js/module.flow.js b/web3.js/module.flow.js
index 5bb0cecead..631337fbbd 100644
--- a/web3.js/module.flow.js
+++ b/web3.js/module.flow.js
@@ -41,7 +41,11 @@ declare module '@solana/web3.js' {
     userdata: Buffer,
   }
 
-  declare export type SignatureStatus = 'Confirmed' | 'SignatureNotFound' | 'ProgramRuntimeError' | 'GenericFailure';
+  declare export type SignatureStatus = 'Confirmed'
+    | 'AccountInUse'
+    | 'SignatureNotFound'
+    | 'ProgramRuntimeError'
+    | 'GenericFailure';
 
   declare export class Connection {
     constructor(endpoint: string): Connection;
diff --git a/web3.js/src/connection.js b/web3.js/src/connection.js
index 6a06bd5bbe..b3b50eaf7d 100644
--- a/web3.js/src/connection.js
+++ b/web3.js/src/connection.js
@@ -101,10 +101,11 @@ const ConfirmTransactionRpcResult = jsonRpcResult('boolean');
  * Expected JSON RPC response for the "getSignatureStatus" message
  */
 const GetSignatureStatusRpcResult = jsonRpcResult(struct.enum([
+  'AccountInUse',
   'Confirmed',
-  'SignatureNotFound',
-  'ProgramRuntimeError',
   'GenericFailure',
+  'ProgramRuntimeError',
+  'SignatureNotFound',
 ]));
 
 /**
@@ -152,7 +153,11 @@ type AccountInfo = {
  *
  * @typedef {string} SignatureStatus
  */
-export type SignatureStatus = 'Confirmed' | 'SignatureNotFound' | 'ProgramRuntimeError' | 'GenericFailure';
+export type SignatureStatus = 'Confirmed'
+  | 'AccountInUse'
+  | 'SignatureNotFound'
+  | 'ProgramRuntimeError'
+  | 'GenericFailure';
 
 /**
  * A connection to a fullnode JSON RPC endpoint
diff --git a/web3.js/src/util/send-and-confirm-transaction.js b/web3.js/src/util/send-and-confirm-transaction.js
index c54d873f65..998a81b8bb 100644
--- a/web3.js/src/util/send-and-confirm-transaction.js
+++ b/web3.js/src/util/send-and-confirm-transaction.js
@@ -15,30 +15,35 @@ export async function sendAndConfirmTransaction(
   transaction: Transaction,
   runtimeErrorOk: boolean = false
 ): Promise<void> {
-  const start = Date.now();
-  const signature = await connection.sendTransaction(from, transaction);
 
-  // Wait up to a couple seconds for a confirmation
-  let i = 4;
+  let sendRetries = 3;
   for (;;) {
-    const status = await connection.getSignatureStatus(signature);
-    switch (status) {
-    case 'Confirmed':
-      return;
-    case 'ProgramRuntimeError':
-      if (runtimeErrorOk) return;
-      //fall through
-    case 'GenericError':
-    default:
-      throw new Error(`Transaction ${signature} failed (${status})`);
-    case 'SignatureNotFound':
-      break;
+    const start = Date.now();
+    const signature = await connection.sendTransaction(from, transaction);
+
+    // Wait up to a couple seconds for a confirmation
+    let status = 'SignatureNotFound';
+    let statusRetries = 4;
+    for (;;) {
+      status = await connection.getSignatureStatus(signature);
+      if (status !== 'SignatureNotFound') {
+        break;
+      }
+
+      await sleep(500);
+      if (--statusRetries <= 0) {
+        const duration = (Date.now() - start) / 1000;
+        throw new Error(`Transaction '${signature}' was not confirmed in ${duration.toFixed(2)} seconds (${status})`);
+      }
     }
 
-    await sleep(500);
-    if (--i < 0) {
-      const duration = (Date.now() - start) / 1000;
-      throw new Error(`Transaction '${signature}' was not confirmed in ${duration.toFixed(2)} seconds (${status})`);
+    if ( (status === 'Confirmed') ||
+         (status === 'ProgramRuntimeError' && runtimeErrorOk) ) {
+      return;
+    }
+
+    if (status !== 'AccountInUse' || --sendRetries <= 0) {
+      throw new Error(`Transaction ${signature} failed (${status})`);
     }
   }
 }