diff --git a/Cargo.lock b/Cargo.lock
index 6c58e2d6c9..abff33a721 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -4440,6 +4440,7 @@ dependencies = [
  "hex",
  "hmac",
  "itertools 0.9.0",
+ "lazy_static",
  "libsecp256k1",
  "log 0.4.8",
  "memmap",
diff --git a/programs/bpf/Cargo.lock b/programs/bpf/Cargo.lock
index 394bfdd967..cf19b778f8 100644
--- a/programs/bpf/Cargo.lock
+++ b/programs/bpf/Cargo.lock
@@ -2121,6 +2121,7 @@ dependencies = [
  "hex",
  "hmac",
  "itertools",
+ "lazy_static",
  "libsecp256k1",
  "log",
  "memmap",
diff --git a/sdk/Cargo.toml b/sdk/Cargo.toml
index 4c01c7ba9f..45b361f6e2 100644
--- a/sdk/Cargo.toml
+++ b/sdk/Cargo.toml
@@ -42,6 +42,7 @@ generic-array = { version = "0.14.3", default-features = false, features = ["ser
 hex = "0.4.2"
 hmac = "0.7.0"
 itertools = { version = "0.9.0" }
+lazy_static = "1.4.0"
 log = { version = "0.4.8" }
 memmap = { version = "0.7.0", optional = true }
 num-derive = { version = "0.3" }
diff --git a/sdk/src/decode_error.rs b/sdk/src/decode_error.rs
index f50e5bfd00..7ca44864d7 100644
--- a/sdk/src/decode_error.rs
+++ b/sdk/src/decode_error.rs
@@ -1,6 +1,6 @@
 use num_traits::FromPrimitive;
 
-/// Allows customer errors to be decoded back to their original enum
+/// Allows custom errors to be decoded back to their original enum
 pub trait DecodeError<E> {
     fn decode_custom_error_to_enum(custom: u32) -> Option<E>
     where
diff --git a/sdk/src/lib.rs b/sdk/src/lib.rs
index c69001323e..5bf9035232 100644
--- a/sdk/src/lib.rs
+++ b/sdk/src/lib.rs
@@ -84,7 +84,23 @@ pub mod entrypoint_deprecated;
 pub mod log;
 pub mod program;
 pub mod program_error;
+
+#[cfg(all(feature = "program", not(target_arch = "bpf")))]
+extern crate lazy_static;
+
+#[cfg(all(feature = "program", not(target_arch = "bpf")))]
 pub mod program_stubs;
+
+// Unused `solana_sdk::program_stubs!()` macro retained for source backwards compatibility with v1.3.x programs
+#[macro_export]
+#[deprecated(
+    since = "1.4.2",
+    note = "program_stubs macro is obsolete and can be safely removed"
+)]
+macro_rules! program_stubs {
+    () => {};
+}
+
 pub mod serialize_utils;
 
 // Modules not usable by on-chain programs
diff --git a/sdk/src/log.rs b/sdk/src/log.rs
index d96c55e6b1..1c6d5f0ea3 100644
--- a/sdk/src/log.rs
+++ b/sdk/src/log.rs
@@ -31,10 +31,16 @@ macro_rules! info {
 /// @param message - Message to print
 #[inline]
 pub fn sol_log(message: &str) {
+    #[cfg(target_arch = "bpf")]
     unsafe {
         sol_log_(message.as_ptr(), message.len() as u64);
     }
+
+    #[cfg(not(target_arch = "bpf"))]
+    crate::program_stubs::sol_log(message);
 }
+
+#[cfg(target_arch = "bpf")]
 extern "C" {
     fn sol_log_(message: *const u8, len: u64);
 }
@@ -45,10 +51,16 @@ extern "C" {
 
 #[inline]
 pub fn sol_log_64(arg1: u64, arg2: u64, arg3: u64, arg4: u64, arg5: u64) {
+    #[cfg(target_arch = "bpf")]
     unsafe {
         sol_log_64_(arg1, arg2, arg3, arg4, arg5);
     }
+
+    #[cfg(not(target_arch = "bpf"))]
+    crate::program_stubs::sol_log_64(arg1, arg2, arg3, arg4, arg5);
 }
+
+#[cfg(target_arch = "bpf")]
 extern "C" {
     fn sol_log_64_(arg1: u64, arg2: u64, arg3: u64, arg4: u64, arg5: u64);
 }
diff --git a/sdk/src/program.rs b/sdk/src/program.rs
index 6058175544..c6b4cf3497 100644
--- a/sdk/src/program.rs
+++ b/sdk/src/program.rs
@@ -1,9 +1,6 @@
 #![cfg(feature = "program")]
 
-use crate::{
-    account_info::AccountInfo, entrypoint::ProgramResult, entrypoint::SUCCESS,
-    instruction::Instruction,
-};
+use crate::{account_info::AccountInfo, entrypoint::ProgramResult, instruction::Instruction};
 
 /// Invoke a cross-program instruction
 pub fn invoke(instruction: &Instruction, account_infos: &[AccountInfo]) -> ProgramResult {
@@ -32,20 +29,28 @@ pub fn invoke_signed(
         }
     }
 
-    let result = unsafe {
-        sol_invoke_signed_rust(
-            instruction as *const _ as *const u8,
-            account_infos as *const _ as *const u8,
-            account_infos.len() as u64,
-            signers_seeds as *const _ as *const u8,
-            signers_seeds.len() as u64,
-        )
-    };
-    match result {
-        SUCCESS => Ok(()),
-        _ => Err(result.into()),
+    #[cfg(target_arch = "bpf")]
+    {
+        let result = unsafe {
+            sol_invoke_signed_rust(
+                instruction as *const _ as *const u8,
+                account_infos as *const _ as *const u8,
+                account_infos.len() as u64,
+                signers_seeds as *const _ as *const u8,
+                signers_seeds.len() as u64,
+            )
+        };
+        match result {
+            crate::entrypoint::SUCCESS => Ok(()),
+            _ => Err(result.into()),
+        }
     }
+
+    #[cfg(not(target_arch = "bpf"))]
+    crate::program_stubs::sol_invoke_signed(instruction, account_infos, signers_seeds)
 }
+
+#[cfg(target_arch = "bpf")]
 extern "C" {
     fn sol_invoke_signed_rust(
         instruction_addr: *const u8,
diff --git a/sdk/src/program_stubs.rs b/sdk/src/program_stubs.rs
index 9228f5a766..809c70d8de 100644
--- a/sdk/src/program_stubs.rs
+++ b/sdk/src/program_stubs.rs
@@ -1,36 +1,54 @@
-//! @brief Syscall stubs when building for non-BPF targets
+//! @brief Syscall stubs when building for programs for non-BPF targets
 
-#[cfg(not(target_arch = "bpf"))]
-#[no_mangle]
-/// # Safety
-pub unsafe fn sol_log_(message: *const u8, length: u64) {
-    let slice = std::slice::from_raw_parts(message, length as usize);
-    let string = std::str::from_utf8(&slice).unwrap();
-    println!("{}", string);
+use crate::{
+    account_info::AccountInfo, entrypoint::ProgramResult, instruction::Instruction,
+    program_error::ProgramError,
+};
+use std::sync::{Arc, RwLock};
+
+lazy_static::lazy_static! {
+    static ref SYSCALL_STUBS: Arc<RwLock<Box<dyn SyscallStubs>>> = Arc::new(RwLock::new(Box::new(DefaultSyscallStubs {})));
 }
 
-#[cfg(not(target_arch = "bpf"))]
-#[no_mangle]
-pub fn sol_log_64_(arg1: u64, arg2: u64, arg3: u64, arg4: u64, arg5: u64) {
-    println!("{} {} {} {} {}", arg1, arg2, arg3, arg4, arg5);
+// The default syscall stubs don't do much, but `set_syscalls()` can be used to swap in
+// alternatives
+pub fn set_syscall_stubs(syscall_stubs: Box<dyn SyscallStubs>) -> Box<dyn SyscallStubs> {
+    std::mem::replace(&mut SYSCALL_STUBS.write().unwrap(), syscall_stubs)
 }
 
-#[cfg(not(target_arch = "bpf"))]
-#[no_mangle]
-pub fn sol_invoke_signed_rust() {
-    println!("sol_invoke_signed_rust()");
+pub trait SyscallStubs: Sync + Send {
+    fn sol_log(&self, message: &str) {
+        println!("{}", message);
+    }
+    fn sol_invoke_signed(
+        &self,
+        _instruction: &Instruction,
+        _account_infos: &[AccountInfo],
+        _signers_seeds: &[&[&[u8]]],
+    ) -> ProgramResult {
+        sol_log("SyscallStubs: sol_invoke_signed() not available");
+        Err(ProgramError::InvalidArgument)
+    }
 }
 
-#[macro_export]
-macro_rules! program_stubs {
-    () => {
-        #[cfg(not(target_arch = "bpf"))]
-        #[test]
-        fn pull_in_externs() {
-            use solana_sdk::program_stubs::{sol_invoke_signed_rust, sol_log_, sol_log_64_};
-            unsafe { sol_log_("sol_log_".as_ptr(), 8) };
-            sol_log_64_(1, 2, 3, 4, 5);
-            sol_invoke_signed_rust();
-        }
-    };
+struct DefaultSyscallStubs {}
+impl SyscallStubs for DefaultSyscallStubs {}
+
+pub(crate) fn sol_log(message: &str) {
+    SYSCALL_STUBS.read().unwrap().sol_log(message);
+}
+
+pub(crate) fn sol_log_64(arg1: u64, arg2: u64, arg3: u64, arg4: u64, arg5: u64) {
+    sol_log(&format!("{} {} {} {} {}", arg1, arg2, arg3, arg4, arg5));
+}
+
+pub(crate) fn sol_invoke_signed(
+    instruction: &Instruction,
+    account_infos: &[AccountInfo],
+    signers_seeds: &[&[&[u8]]],
+) -> ProgramResult {
+    SYSCALL_STUBS
+        .read()
+        .unwrap()
+        .sol_invoke_signed(instruction, account_infos, signers_seeds)
 }
diff --git a/sdk/src/pubkey.rs b/sdk/src/pubkey.rs
index d6c1350af7..64e31dd0ac 100644
--- a/sdk/src/pubkey.rs
+++ b/sdk/src/pubkey.rs
@@ -204,12 +204,17 @@ impl Pubkey {
     }
 
     /// Log a `Pubkey` from a program
-    #[cfg(feature = "program")]
     pub fn log(&self) {
-        extern "C" {
-            fn sol_log_pubkey(pubkey_addr: *const u8);
-        };
-        unsafe { sol_log_pubkey(self.as_ref() as *const _ as *const u8) };
+        #[cfg(all(feature = "program", target_arch = "bpf"))]
+        {
+            extern "C" {
+                fn sol_log_pubkey(pubkey_addr: *const u8);
+            };
+            unsafe { sol_log_pubkey(self.as_ref() as *const _ as *const u8) };
+        }
+
+        #[cfg(all(feature = "program", not(target_arch = "bpf")))]
+        crate::program_stubs::sol_log(&self.to_string());
     }
 }