diff --git a/programs/bpf_loader/src/serialization.rs b/programs/bpf_loader/src/serialization.rs
index e6b1b513a7..3fae5ba12e 100644
--- a/programs/bpf_loader/src/serialization.rs
+++ b/programs/bpf_loader/src/serialization.rs
@@ -3,15 +3,12 @@ use solana_rbpf::{aligned_memory::AlignedMemory, ebpf::HOST_ALIGN};
 use solana_sdk::{
     account::{ReadableAccount, WritableAccount},
     bpf_loader_deprecated,
-    entrypoint::{MAX_PERMITTED_DATA_INCREASE, PARAMETER_ALIGNMENT},
+    entrypoint::{BPF_ALIGN_OF_U128, MAX_PERMITTED_DATA_INCREASE},
     instruction::InstructionError,
     keyed_account::KeyedAccount,
     pubkey::Pubkey,
 };
-use std::{
-    io::prelude::*,
-    mem::{align_of, size_of},
-};
+use std::{io::prelude::*, mem::size_of};
 
 /// Look for a duplicate account and return its position if found
 pub fn is_dup(accounts: &[KeyedAccount], keyed_account: &KeyedAccount) -> (bool, usize) {
@@ -168,7 +165,7 @@ pub fn get_serialized_account_size_aligned(
             + size_of::<u64>()  // data len
             + data_len
             + MAX_PERMITTED_DATA_INCREASE
-            + (data_len as *const u8).align_offset(align_of::<u128>())
+            + (data_len as *const u8).align_offset(BPF_ALIGN_OF_U128)
             + size_of::<u64>(), // rent epoch
     )
 }
@@ -227,7 +224,7 @@ pub fn serialize_parameters_aligned(
                 .map_err(|_| InstructionError::InvalidArgument)?;
             v.resize(
                 MAX_PERMITTED_DATA_INCREASE
-                    + (v.write_index() as *const u8).align_offset(PARAMETER_ALIGNMENT),
+                    + (v.write_index() as *const u8).align_offset(BPF_ALIGN_OF_U128),
                 0,
             )
             .map_err(|_| InstructionError::InvalidArgument)?;
@@ -277,7 +274,7 @@ pub fn deserialize_parameters_aligned(
 
             account.set_data_from_slice(&buffer[start..data_end]);
             start += pre_len + MAX_PERMITTED_DATA_INCREASE; // data
-            start += (start as *const u8).align_offset(align_of::<u128>());
+            start += (start as *const u8).align_offset(BPF_ALIGN_OF_U128);
             start += size_of::<u64>(); // rent_epoch
         }
     }
@@ -406,7 +403,7 @@ mod tests {
         assert_eq!(&program_id, de_program_id);
         assert_eq!(instruction_data, de_instruction_data);
         assert_eq!(
-            (&de_instruction_data[0] as *const u8).align_offset(align_of::<u128>()),
+            (&de_instruction_data[0] as *const u8).align_offset(BPF_ALIGN_OF_U128),
             0
         );
         for ((account, account_info), key) in accounts.iter().zip(de_accounts).zip(keys.clone()) {
@@ -419,7 +416,7 @@ mod tests {
             assert_eq!(account.rent_epoch(), account_info.rent_epoch);
 
             assert_eq!(
-                (*account_info.lamports.borrow() as *const u64).align_offset(align_of::<u64>()),
+                (*account_info.lamports.borrow() as *const u64).align_offset(BPF_ALIGN_OF_U128),
                 0
             );
             assert_eq!(
@@ -427,7 +424,7 @@ mod tests {
                     .data
                     .borrow()
                     .as_ptr()
-                    .align_offset(align_of::<u128>()),
+                    .align_offset(BPF_ALIGN_OF_U128),
                 0
             );
         }
diff --git a/programs/bpf_loader/src/syscalls.rs b/programs/bpf_loader/src/syscalls.rs
index 7448890e08..312befd3bf 100644
--- a/programs/bpf_loader/src/syscalls.rs
+++ b/programs/bpf_loader/src/syscalls.rs
@@ -16,7 +16,7 @@ use solana_sdk::{
     bpf_loader, bpf_loader_deprecated,
     bpf_loader_upgradeable::{self, UpgradeableLoaderState},
     clock::Clock,
-    entrypoint::{MAX_PERMITTED_DATA_INCREASE, SUCCESS},
+    entrypoint::{BPF_ALIGN_OF_U128, MAX_PERMITTED_DATA_INCREASE, SUCCESS},
     epoch_schedule::EpochSchedule,
     feature_set::{
         allow_native_ids, check_seed_length, close_upgradeable_program_accounts, cpi_data_cost,
@@ -825,7 +825,7 @@ impl SyscallObject<BpfError> for SyscallAllocFree {
         result: &mut Result<u64, EbpfError<BpfError>>,
     ) {
         let align = if self.aligned {
-            align_of::<u128>()
+            BPF_ALIGN_OF_U128
         } else {
             align_of::<u8>()
         };
diff --git a/sdk/program/src/entrypoint.rs b/sdk/program/src/entrypoint.rs
index 6e8619cfbe..3d56ceb09a 100644
--- a/sdk/program/src/entrypoint.rs
+++ b/sdk/program/src/entrypoint.rs
@@ -252,8 +252,8 @@ unsafe impl std::alloc::GlobalAlloc for BumpAllocator {
 /// Maximum number of bytes a program may add to an account during a single realloc
 pub const MAX_PERMITTED_DATA_INCREASE: usize = 1_024 * 10;
 
-// Parameters passed to the entrypoint input buffer are aligned on 8-byte boundaries
-pub const PARAMETER_ALIGNMENT: usize = 8;
+/// `assert_eq(std::mem::align_of::<u128>(), 8)` is true for BPF but not for some host machines
+pub const BPF_ALIGN_OF_U128: usize = 8;
 
 /// Deserialize the input arguments
 ///
@@ -312,7 +312,7 @@ pub unsafe fn deserialize<'a>(input: *mut u8) -> (&'a Pubkey, Vec<AccountInfo<'a
                 from_raw_parts_mut(input.add(offset), data_len)
             }));
             offset += data_len + MAX_PERMITTED_DATA_INCREASE;
-            offset += (offset as *const u8).align_offset(PARAMETER_ALIGNMENT); // padding
+            offset += (offset as *const u8).align_offset(BPF_ALIGN_OF_U128); // padding
 
             #[allow(clippy::cast_ptr_alignment)]
             let rent_epoch = *(input.add(offset) as *const u64);